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目的对广州市大学城某高校合唱团甲型H1N1流感暴发疫情进行分析,探讨流行特征及采取的防制措施,为控制暴发提供科学依据。方法设计统一调查表,对甲型H1N1流感暴发疫情进行现场调查,采集病例咽拭子标本以及血清标本进行甲型H1N1流感病毒核酸检测以及血清抗体检测,采用excell录入数据,Spss10.0软件进行统计分析。结果该起疫情累计确诊甲型H1N1流感病例36例,罹患率为60%(36/60)。36例病例中,男21例,女15例,罹患率分别为61.76%(21/34)和57.69%(15/26),χ2=0.102,P=0.750。从9月4日至疫情结案后7d,合唱团所在学校门诊流感样病例就诊比例为4.32%～11.67%,平均为8.77%,大学城10所高校为4.9%～12.09%,平均为9.08%。相关系数R=0.699(P=0.00)。结论早报告、加强发热病例的隔离治疗以及密切接触者的医学观察,是控制甲型H1N1流感疫情的有效措施。不能忽视甲型H1N1流感隐性感染者,在密切接触者病例排查中除了采集咽拭子标本外,尽可能采集双份血清标本,从而全面评估疫情态势。
Objective To analyze the epidemic situation of Influenza A (H1N1) outbreaks in a college choir in the university city of Guangzhou and discuss the epidemiological characteristics and the preventive measures taken so as to provide a scientific basis for controlling the outbreak. Methods A unified questionnaire was designed to investigate the outbreak of influenza A (H1N1). Samples of throat swabs and serum samples were collected for nucleic acid detection of influenza A (H1N1) virus and detection of serum antibodies. The excell data and Spss 10.0 software were used for statistical analysis analysis. Results Thirty-six cases of Influenza A (H1N1) were diagnosed during the outbreak. The attack rate was 60% (36/60). Among the 36 cases, there were 21 males and 15 females with the prevalence rates of 61.76% (21/34) and 57.69% (15/26), respectively. The incidences of χ2 = 0.102 and P = 0.750. From September 4 to July 7, 2007, outpatient influenza-like illness cases in the choir school ranged from 4.32% to 11.67% with an average of 8.77%. Universities in the University City ranged from 4.9% to 12.09% with an average of 9.08%. The correlation coefficient R = 0.699 (P = 0.00). Conclusions The earlier report, to strengthen the isolated treatment of febrile cases and medical observation of close contacts, is an effective measure to control the outbreak of influenza A (H1N1). Can not be ignored influenza A H1N1 influenza infection, in close contact with the case investigation in addition to collecting throat swab specimens, as much as possible to collect two copies of serum samples in order to fully assess the outbreak situation.