In this paper we studied a key control project in QinghaiTibet Railway construction. The project included the oxygen supplying system, the ventilation and air changing system measure of tunnel environment, monitoring and comprehensive treatment on airborne dust and toxic and harmful gases, hygiene intervention with builders in Fenghuoshan Tunnel construction. In the worst sector of the whole Qinghai-Tibet Railway line, we acquired a good achievement of the lowest incidence rate of altitude disease. Hence the Fenghuoshan Tunnel was joined up in advance, which set up a new record for frozen soil tunnel construction at high altitudes. The application of health care measure for tunnel construction promised rapid results. In this paper we studied a key control project in QinghaiTibet Railway construction. The project included the oxygen supplying system, the ventilation and air changing system measure of tunnel environment, monitoring and comprehensive treatment on airborne dust and toxic and harmful gases, hygiene intervention with the builders in Fenghuoshan Tunnel construction. In the worst sector of the whole Qinghai-Tibet Railway line, we acquired a good achievement of the the highest incidence rate of altitude disease. for frozen soil tunnel construction at high altitudes. The application of health care measure for tunnel construction promised rapid results.