异硫氰酸酯和炔是有机反应中重要的部分,通过环加成反应、亲核反应等广泛应用于合成杂环化合物。异硫氰酸酯和炔官能团可以在同一分子内反应合成杂环,也可以多组分一锅煮反应合成杂环。相比较而言,异硫氰酸酯和炔在参与反应时,异硫氰酸酯的硫原子更易进攻反应底物,因此合成的杂环通常为含硫杂环。综述了异硫氰酸酯和炔用于合成苯并[1,3]噻嗪环、噻唑啉环和噻喃环等反应。 Isothiocyanates and alkynes are an important part of organic reactions. They are widely used in the synthesis of heterocyclic compounds through cycloaddition reactions, nucleophilic reactions and the like. Isothiocyanates and alkyne functional groups can react in the same molecule to synthesize heterocyclic rings, and can also synthesize heterocyclic rings in one-pot reaction of multiple components. In contrast, isothiocyanate and alkyne participate in the reaction, the isothiocyanate sulfur atom more offensive reaction substrate, the synthesis of heterocyclic ring is usually sulfur. The isothiocyanates and alkynes are reviewed for the synthesis of benzo [1,3] thiazine ring, thiazoline ring and thiopyran ring.