颅内动脉瘤是一种由多种环境因素和多个基因共同作用的多基因疾病[1]。近年来,对颅内动脉瘤相关致病基因的研究逐渐被人们所重视并获得了深入研究。细胞外基质的破裂很可能是颅内动脉瘤形成中的一种病理生理学表现,与遗传缺陷的组织和细胞外基质相关联[2]。在许多破裂的颅内动 Intracranial aneurysm is a multi-gene disease caused by a variety of environmental factors and multiple genes [1]. In recent years, the study of the causative genes related to intracranial aneurysms has gradually been valued by people and obtained in-depth study. The rupture of extracellular matrix is ​​likely to be a pathophysiological manifestation of intracranial aneurysm, which is associated with the genetic defects of the tissue and extracellular matrix [2]. In many broken intracranial movements