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作者研究了黄芪、人参和黄芩的水提物诱导培养的血管平滑肌细胞(VSMC)中NO合成的机理。Northernblot分析表明,以水提取物处理导致VSMC中的诱导NO合酶(iNOS)基因转录的增加。免疫组织化学和免疫斑点证明,在以水提物处理后VSMC中iNOS蛋白质显著增加。内皮衍生的NO松弛VSMC?
The authors studied the mechanism of NO synthesis in vascular smooth muscle cells (VSMC) induced by aqueous extracts of Astragalus membranaceus, Panax Ginseng and Radix Astragali. Northern blot analysis showed that treatment with water extract resulted in increased transcription of the inducible NO synthase (iNOS) gene in VSMCs. Immunohistochemistry and immunoblot demonstrated that the iNOS protein was significantly increased in VSMCs after treatment with water extracts. Endothelium-derived NO relaxes VSMCs?