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目的:探讨发病后不同时间及不同梗塞面积的脑梗塞患者血浆纤维结合蛋白的变化及其临床意义。方法:选择脑梗塞患者493例,健康体检者349例,应用日立7600-020全自动生化分析仪检测清晨空腹状态下血浆纤维结合蛋白(Fn),并按脑梗塞发病时间及梗塞面积不同进一步分组,与对照组进行比较。结果:脑梗塞发病后患者血浆Fn在48h内已升高,之后逐渐降低,但至14d后仍高于正常水平。脑梗塞面积越大,血浆Fn升高越显著。结论:血浆Fn变化与脑梗塞病情密切相关,血浆Fn可作为脑梗塞治疗时主要监测指标之一。
Objective: To investigate the changes and clinical significance of plasma fibronectin in patients with cerebral infarction at different time and different infarct areas. Methods: 493 patients with cerebral infarction and 349 healthy subjects were enrolled in this study. Plasma Fibronectin (Fn) was detected with Hitachi 7600-020 automatic biochemical analyzer in early morning fasting state, and further divided into groups according to the time of onset of cerebral infarction and infarct size , Compared with the control group. Results: Fn in patients with cerebral infarction increased within 48 hours after the onset of cerebral infarction, and then gradually decreased, but still higher than the normal level after 14d. The larger the area of cerebral infarction, plasma Fn increased significantly. Conclusion: The changes of Fn in plasma are closely related to the severity of cerebral infarction. Plasma Fn can be used as one of the main indicators in the treatment of cerebral infarction.