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为评估溶栓治疗的时间与心脏破裂的危险和总死亡率的关系,作者对采用随机对照溶栓疗法治疗的急性心肌梗塞病例进行了Meta分析。 方法:作者收集1989年3月1日以前报道的具备下列各项的全部文章:(1)报道用溶栓药治疗急性心肌梗塞的随机对照试验;(2)关于心脏破裂或死亡率的资料;(3)心绞痛至溶栓治疗的平均时间;5个或5个以上的最终结果。溶栓对心脏破裂影响分析的附加标准是:所报道的尸检数量必须≥试验中死亡病例数的50％。 统计学方法:收集这些试验的结果,以估测与
To assess the timing of thrombolytic therapy in relation to the risk of heart rupture and overall mortality, the authors performed a meta-analysis of patients with acute myocardial infarction treated with randomized controlled thrombolytic therapy. METHODS: The authors collected all the articles previously reported on March 1, 1989, with the following items: (1) Randomized controlled trials of thrombolytic drugs for the treatment of acute myocardial infarction; (2) Information on cardiac rupture or mortality; (3) the average time from angina to thrombolytic therapy; five or more of the final results. An additional criterion for the analysis of the effects of thrombolysis on heart rupture is that the number of autopsies reported must be ≥ 50% of the number of deaths in the trial. Statistical Methods: The results of these tests were collected to estimate the sum