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目的许多心血管变量存在着近日节律,心肌收缩反应及收缩蛋白基因表达是否存在着相应的周期性改变是值得深入研究。方法在24 h 内采用直接在大白鼠左心室内插入左心导管记录左室压(LVP)和左室压力微分最大值(dp/dt max)以及检测比较心肌细胞的αMHC基因表达改变。结果LVP(P<0.001)、dp/dt max (P< 0.001) 和αMHC(P<0.01)的变化存在着近日节律。通过比较三者近日节律振幅显示LVP的振幅最大,dp/dt max 次之,αMHC基因表达的节律振幅再次之,表明心肌收缩力的近日节律的变化是由心肌细胞内在和外在作用的结果。结论αMHC基因表达水平的近日变化是决定着心肌收缩功能的近日节律的因素之一。
Purpose There are many cardiovascular variables exist rhythms, myocardial contractile response and contractile protein gene expression whether there is a corresponding cyclical changes deserve further study. Methods The changes of left ventricular pressure (LVP), left ventricular pressure (dp / dt max) and the expression of αMHC gene in cardiomyocytes were measured within 24 h by inserting left ventricular catheter directly into the left ventricle of rats. Results There were recent rhythms of LVP (P <0.001), dp / dt max (P <0.001) and αMHC (P <0.01). By comparing the three recent rhythm amplitude showed LVP amplitude maximum, dp / dt max followed by α-MHC gene expression of the rhythm amplitude again, indicating that changes in recent rhythm of myocardial contractility by the intrinsic and extrinsic role of myocardial cells result. Conclusion Recent changes in α-MHC gene expression is one of the factors determining the recent rhythm of myocardial systolic function.