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目的 探讨高胰岛素血症对血清胆固醇 (TC)、甘油三酯 (TG)、载脂蛋白 (APOA1)、载脂蛋白(APOB)的影响。方法 首次发作住院精神分裂症患者 ,以单纯使用抗精神病药物者为对照组 (2 0例 ) ,以抗精神病药物联合使用胰岛素治疗者为治疗组 (30例 ) ,治疗 2 0d后和治疗前的TC、TG、APOA1、APOB进行比较。结果 对照组治疗前后血清TC、TG、APOA1、APOB均无统计数差异 (P >0 .0 5 ) ,治疗组APOA1无统计学差异 (P >0 .0 5 ) ,试验组治疗后TC (P <0 .0 0 1)、TG (P <0 .0 5 )、APOB (P <0 .0 2 )均较治疗前数值升高。结论 高胰岛素血症可能通过影响人体脂质代谢 ,使TC、TG、APOB升高 ,从而引起高血压、冠心病、动脉粥样硬化等疾病的发生
Objective To investigate the effects of hyperinsulinemia on serum cholesterol (TC), triglyceride (TG), apolipoprotein (APOA1) and apolipoprotein (APOB). Methods Inpatients with first episode of schizophrenia were treated with antipsychotics alone (control group) (20 patients), antipsychotics plus insulin therapy group (30 patients), and after 20 days of treatment and before treatment TC, TG, APOA1, APOB. Results There was no significant difference in serum TC, TG, APOA1 and APOB before and after treatment in the control group (P> 0.05), and APOA1 in the treatment group had no statistical difference (P> 0.05) <0. 01), TG (P <0. 05) and APOB (P <0. 0 2) were higher than those before treatment. Conclusion Hyperinsulinemia may cause the increase of TC, TG and APOB by influencing the lipid metabolism of the human body, causing the occurrence of diseases such as hypertension, coronary heart disease and atherosclerosis