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应用流式细胞仪检测强直性脊柱炎(AS)及类风湿关节炎(RA)患者外周血淋巴细胞(PBL)表面IL-2受体(IL-2R)及经PHA刺激、体外培养产生的IL-2。结果表明,AS患者PBL表达IL-2R无明显增加,而RA患者则明显高于正常人及AS患者(P<0.01);AS及RA患者PBL体外培养产生IL-2明显多于正常人(P<0.01),提示IL-2异常在AS及RA患者免疫功能失调中起重要作用。
Flow cytometry was used to detect IL-2R (IL-2R) on the peripheral blood lymphocytes (PBL) in patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) and IL- -2. The results showed that IL-2R expression of PBL in patients with AS was not significantly increased, but RA patients were significantly higher than those in normal subjects and patients with AS (P <0.01); IL-2 production of PBL in AS and RA patients was significantly higher than that in normal subjects <0.01), suggesting that IL-2 abnormalities play an important role in immune dysfunction in patients with AS and RA.