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临床前药效学评价,主要包括三方面内容,一是化合物对疾病的实验治疗效果,二是化合物的一般药理作用,三是作用部位和机制.治疗效果是研制药物的着眼点,是一切工作的基础,疾病不同评价方法各异.作用机制的研究在新药评价中不但是“锦上添花”的工作,而且是药效评价的补充,对评价一个新药的价值也是很有意义的.一般药理学研究是介于上述二者之间的工作.在药物研制的发展过程中,也具有重要作用.世界卫生组织(WHO)在1975年“新药评价的指导原则”的技术报告中指出:“当发现一种化合物具有某种药理活性时,应进行广泛的动物药理学试验,以测定其可能具有的其它药理活性”.“应在机体的主要器官系统上进行研究,以揭示药物的其它效应”“可能的不良反应、哪种组
Preclinical pharmacodynamic evaluation includes three aspects: one is the experimental therapeutic effect of the compound on the disease; the other is the general pharmacological action of the compound; the third is the action site and mechanism; and the therapeutic effect is the focus of the development of the drug and all the work Based on the different evaluation methods of disease vary.Research on the mechanism of action in the evaluation of new drugs is not only ”icing on the cake,“ the work, but also to supplement the evaluation of the effectiveness of the evaluation of the value of a new drug is also of great significance. Learning research is a work in the middle of the above two aspects and also plays an important role in the development of drug development.World Health Organization (WHO) in 1975, ”New Drug Evaluation Guiding Principles,“ the technical report states: ”When a compound is found to possess some pharmacological activity, a wide range of animal pharmacological tests should be conducted to determine the other pharmacological activities that it may have.“. ”Studies should be conducted on the body’s major organ systems to reveal Other effects of the drug “” possible adverse reactions, what kind of group