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目的探讨超声检测实验性肝纤维化肝循环指数(HCI)及骨强度的作用。方法40只健康家兔采用硫代乙酰胺为唯一饮用水制备肝纤维化模型,分别于0、8、12、16、20周测量外周血清骨钙素(BGP)水平;应用超声检测不同时期肝纤维化HCI及骨声波传导速度(SOS),病理对照观察肝纤维化程度及骨骼结构变化。结果HCI实验组S2、S3、S4期与对照组S0期间比较差异有显著性意义(P<0.05),实验组间对比S4期与S1、S2期之间差异有显著性意义(P<0.05)。实验兔肝纤维化股骨SOS随纤维化程度加重而降低,实验组S3、S4期与对照组S0间差异有显著性意义;血清BGP浓度实验组与对照组间差异有显著性意义(P<0.05)。结论超声检测HCI及SOS,对慢性肝病时肝储备功能和骨骼强度的评估具有积极作用。
Objective To investigate the effect of ultrasound on hepatic circulation index (HCI) and bone strength in experimental liver fibrosis. Methods Forty healthy rabbits were given thioacetamide as the only drinking water to prepare the model of hepatic fibrosis. Peripheral serum BGP was measured at 0, 8, 12, 16 and 20 weeks. Ultrasound was used to detect the expression of BGP Fibrosis HCI and bone acoustic wave velocity (SOS), pathological control liver fibrosis and bone structure changes. Results There was significant difference in the HCI experimental group between S2, S3, S4 and S0 (P <0.05), there was significant difference between the experimental group and S4, S1, S2 (P <0.05) . The level of SOS in the experimental rabbit hepatic fibrosis decreased with the degree of fibrosis, and there was significant difference between the experimental group and the control group in S 3 and S 4. There was significant difference between serum BGP concentration and the control group (P <0.05 ). Conclusions Ultrasound examination of HCI and SOS has a positive effect on assessment of liver function and bone strength in chronic liver disease.