论文部分内容阅读
目的探讨Ⅰ型胶原α_2链(COLⅠα_2)PvuⅡ基因多态性与青藏高原氟暴露地区儿童氟斑牙的关系。方法对所选调查对象进行氟斑牙检查,分为氟斑牙组(氟斑牙儿童,60例)和非氟斑牙组(健康儿童,60例),并抽取外周血进行COLⅠα_2PvuⅡ基因多态性分析。结果氟斑牙组儿童COLⅠα_2PvuⅡ基因型PP分布频率低于非氟斑牙组(16.7%vs.60.0%)(P<0.01),pp分布频率高于非氟斑牙组(58.3%vs.18.3%)(P<0.01)。氟斑牙组和非氟斑牙组Pp分布频率分别为25.0%和21.7%。结论 COLⅠα_2PvuⅡ基因多态性与高原地区儿童氟斑牙有明显的关联。
Objective To investigate the relationship between the PvuⅡ gene polymorphism of type Ⅰ collagen α_2 chain (COLⅠα_2) and dental fluorosis in children exposed to fluoride in the Tibetan Plateau. Methods The dental fluorosis test was performed on the selected subjects and divided into dental fluorosis group (60 children with dental fluorosis) and non-dental fluorosis group (60 children), and the peripheral blood samples were collected for COLⅠα_2PvuⅡ gene polymorphism Sexual analysis. Results The distribution frequency of PP in COLⅠα_2PvuⅡ genotype in children with dental fluorosis was lower than that in non-fluorosis dental group (16.7% vs.60.0%) (P <0.01), and the distribution frequency of pp was higher than that in non-dental fluorosis group (58.3% vs.18.3% ) (P <0.01). The distribution frequency of Pp in dental fluorosis group and non-dental fluorosis group was 25.0% and 21.7% respectively. Conclusions COL Ⅰ α 2 Pvu Ⅱ gene polymorphism is significantly associated with dental fluorosis in children at high altitude.