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目前对于内分泌辅助治疗后乳癌的生物行为改变以及复发病变中雌激素和黄体酮受体的影响等情况了解得不多。作者用 N-亚硝基甲脲在 Sprague-Dawley鼠诱发了乳癌。实验分为两组,每组为40只鼠,给予50μg 和200μg 不同剂量的 Tamoxifen 辅助治疗,并设对照组以资比较。此药可延长肿瘤的诱发时间和减少肿瘤的总数。如已出现肿瘤,Tamoxifen 的
At present, little is known about the biological behavior of breast cancer after endocrine adjuvant therapy and the effects of estrogen and progesterone receptors in relapsing lesions. The authors used N-nitrosomethylurea to induce breast cancer in Sprague-Dawley rats. The experiments were divided into two groups. Each group consisted of 40 rats. 50 μg and 200 μg different doses of Tamoxifen adjuvant therapy were used, and the control group was compared for comparison. This medicine can prolong the time of tumor induction and reduce the total number of tumors. If there has been a tumor, Tamoxifen