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亚硫酸氫鈉甲萘醌及其制剂在一般藥典中均采用重量法或容量法。因其均需經过抽提手續,費时較多;而甲萘醌在鹼性溶液中極易破坏,并需避光操作,且所用的检品数量較大,不适于制剂中的含量测定。亚硫酸氫鈉甲萘醌在酸性或鹼性溶液中均成甲萘醌而析出,故可利用测定甲萘醌的方法来测定,已見諸文献的甲萘醌比色法甚多,如:(1)与甲醇鈉液作用,或与濃硫酸
Sodium thiourea menaquinone and its formulations are used in the general pharmacopoeia Gravimetric or volumetric method. Because they are subject to extraction procedures, more time-consuming; and menadione in alkaline solution easily destroyed, and the need to avoid light operation, and the use of a large number of seized, not suitable for the determination of the content of the preparation . Menadione sodium bisulfite in both acidic or alkaline solution of menaquinone and precipitation, it can be used to determine the method of menadine determination, have been seen in many literature menadione colorimetric method, such as: (1) with sodium methoxide role, or with concentrated sulfuric acid