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目的探讨血清降钙素原(PCT)在重症肺炎治疗中的指导作用。方法选取2013年1月~2015年1月来我院就诊的68例重症肺炎患者,将其作为观察组;选取同期入我院就诊的68例轻症肺炎患者,将其作为对照组。对两组患者的血清PCT、C反应蛋白(CRP)、白细胞(WBC)计数、中性粒细胞(N)百分比与体温进行比较分析。结果观察组的血清PCT与CRP明显高于对照组(P<0.05),两组WBC计数与N百分比及体温差异无统计学意义(P>0.05)。随着PCT水平的提升,需要呼吸机辅助呼吸的患者比例也有明显提升,病死率、抗生素使用时间与住院时间均有不同程度的提升(P<0.05)。结论血清PCT对重症肺炎的诊断、治疗、预后均有重要指导作用。
Objective To investigate the role of serum procalcitonin (PCT) in the treatment of severe pneumonia. Methods Seventy-eight patients with severe pneumonia treated in our hospital from January 2013 to January 2015 were selected as the observation group. Sixty-eight patients with mild pneumonia admitted to our hospital during the same period were selected as the control group. The levels of serum PCT, C-reactive protein (CRP), white blood cell (WBC) counts, percentage of neutrophils (N) and body temperature in two groups were compared. Results The serum PCT and CRP in the observation group were significantly higher than those in the control group (P <0.05). There was no significant difference in WBC count, N percentage and body temperature between two groups (P> 0.05). As the level of PCT increased, the proportion of patients requiring ventilator-assisted breathing increased significantly. The case fatality rate, antibiotic use time and hospital stay were all improved to some extent (P <0.05). Conclusions Serum PCT plays an important role in the diagnosis, treatment and prognosis of severe pneumonia.