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目的观察自拟丹楂降脂方联合尼莫地平与阿司匹林治疗原发性高血压合并血脂异常的疗效。方法将60例确诊为原发性高血压合并血脂异常患者随机分为观察组与对照组。观察组30例,应用自拟丹楂降脂方联合尼莫地平与阿司匹林治疗;对照组30例,应用辛伐他汀联合尼莫地平与阿司匹林治疗,连续治疗12周。结果两组总有效率比较差异无统计学意义(90.0%vs 86.7%,P>0.05)。两组治疗后与治疗前比较均能有效降低血压、TC、TG和升高HDL-C(P均<0.05)。两组均无明显不良反应,疗程中均无心脑血管事件发生。结论自拟丹楂降脂方联合尼莫地平与阿司匹林治疗原发性高血压合并血脂异常患者,能有效降低血压、TC、TG和升高HDL-C,且安全有效。
Objective To observe the curative effect of self-made hawthorn lipid-lowering prescription combined with nimodipine and aspirin in the treatment of essential hypertension with dyslipidemia. Methods Sixty patients with primary hypertension and dyslipidemia were randomly divided into observation group and control group. 30 cases in the observation group were treated with self-made hawthorn lipid-lowering prescription combined with nimodipine and aspirin. In the control group, 30 cases were treated with simvastatin combined with nimodipine and aspirin for 12 weeks. Results There was no significant difference in the total effective rate between the two groups (90.0% vs 86.7%, P> 0.05). After treatment, both groups were able to lower blood pressure, TC, TG and HDL-C (all P <0.05). No significant adverse reactions in both groups, no cardiovascular events during the course of treatment. CONCLUSIONS: The combination of decoction of Navelbine and nimodipine in the treatment of patients with essential hypertension complicated with dyslipidemia can effectively reduce blood pressure, TC, TG and increase HDL-C, and is safe and effective.