脑缺血的发生发展与兴奋性氨基酸、钙超载、自由基、血小板活化因子(PAF)和一氧化氮(NO)等密切相关。银杏叶提取物(EGb)含银杏苦内酯、银杏黄酮等成分,具有广泛的生物活性。药理作用研究表明其具有抗PAF、抗氧化及减轻谷氨酸的兴奋毒等作用。本文就EGb的抗PAF作用、抗氧化作用及其与NO和兴奋性氨基酸的关系等方面介绍EGb对脑缺血的保护作用,并就EGb的开发利用作一展望 The occurrence and development of cerebral ischemia are closely related to excitatory amino acids, calcium overload, free radicals, platelet activating factor (PAF) and nitric oxide (NO). Ginkgo biloba extract (EGb) contains ginkgo-bilobalactone, ginkgo biloba flavonoids and other ingredients, and has a wide range of biological activities. Pharmacological studies have shown that it has anti-PAF, anti-oxidation and glutamate excitatory effects. In this paper, the protective effect of EGb on cerebral ischemia was introduced in terms of the anti-PAF effect of EGb, antioxidation and its relationship with NO and excitatory amino acids, and a prospect was made for the development and utilization of EGb.