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本文报道了河北产东亚钳蝎毒及从粗毒中纯化的抗癫痫肽的抗惊厥作用,本实验用咖啡因、美解眠、士的宁引起惊厥,用生理盐水作空白对照,安定做阳性对照。生理盐水对照组,惊厥发生率均达100%;严重惊厥发作率分别为50%、70%、50%;死亡率分别为40%、30%、50%,各组惊厥平均总持续时间为115min、59.5min、72min。安定对抗咖啡因惊厥的作用较小(P>O.05);但使美解眠和士的宁惊厥各项指标显著下降(P<0.05)。抗癫痫肽对抗咖啡因惊厥的作用较强,四项指标均显著下降(P<0.01),使美解眠惊厥各项指标亦明显下降(P<0.01),但稍弱;对抗士的宁惊厥的作用强度与安定相似(P<0.05)。蝎毒的抗惊厥作用较抗癫痫肽弱,与空白对照组比较差异不显著。
This article reports the anticonvulsant effects of Toadstool Toxicosis and anti-epileptic peptides purified from crude poisons in Hebei Province. In this study, caffeine, methoquinone, and strychnine caused convulsions, and normal saline was used as a blank control. Control. In the saline control group, the incidence of convulsions was 100%; the incidence of severe convulsions was 50%, 70%, and 50%; the mortality rates were 40%, 30%, and 50%, respectively. The average duration of convulsions in each group was 115 minutes. , 59.5 min, 72 min. The effect of diazepam on caffeine convulsions was smaller (P>O.05); however, all indexes of the US Xiemian and Shining Ningjing were significantly decreased (P<0.05). The effect of antiepileptic peptide against caffeine convulsions was stronger, and all four indicators were significantly decreased (P<0.01). The indicators of beauty sleep dispelling were also significantly decreased (P<0.01), but slightly weaker; opposed to strychnine The intensity of the effect was similar to that of diazepam (P<0.05). The anticonvulsant effect of scorpion venom was weaker than that of antiepileptic peptides, and there was no significant difference compared with the blank control group.