【摘 要】
：
α-latrotoxin (α-LTX), a neurotoxin from black-widow spider, causes vesicles release in presynapse of nerve terminal after binding to specific membrane recepto
【机 构】
：
Institute of Biophysics and Biochemistry,National Laboratory of Biomacromolecules
【基金项目】
：
国家自然科学基金;The National Basic Research Program of China
论文部分内容阅读
α-latrotoxin (α-LTX), a neurotoxin from black-widow spider, causes vesicles release in presynapse of nerve terminal after binding to specific membrane receptors. α-LTXN4C is an effective tool binding to calcium independent receptor for latrotoxin (CIRL), which is used to elucidate the mechanism of receptor-mediated signal pathway. In our study on the pancreaticαcells, we found thatα-LTX inserts into the plasma membrane and forms stable non-selective cation channels. The influx of extracellular Ca2+ through the channels causes massive Ca2+-dependent exocytosis of insulin-containing vesicles, whereas, α-LTXN4C, binding with its receptor CIRL in extracellular divalent cation-dependent way, increases [Ca2+]i by mobilization of the intracellular calcium stores.
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