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目的探讨乙型肝炎病毒前C区和C基因启动子基因变异与肝细胞癌发生的关系。方法采用实时荧光PCR检测29例慢性乙型肝炎(CHB),27例乙型肝炎肝硬化(LC),26例HBV相关肝细胞癌(HCC)患者血清HBV前C区G1896A和BCP区A1762T/G1764A的变异情况。结果HCC组和LC组前C区G1896A和BCP区A1762T/G1764A变异率均显著高于CHB组(p≤0.005),HCC组和LC组间无显著差异(p>0.05)。结论乙型肝炎病毒C基因启动子和前C区基因变异与肝细胞癌、肝硬化的发生密切相关。
Objective To investigate the relationship between hepatitis C virus pre-C and C gene promoter mutations and the occurrence of hepatocellular carcinoma. Methods The serum pre-HBV G1896A and A1762T / G1764A of BCP were detected by real-time fluorescence PCR in 29 patients with chronic hepatitis B (CHB), 27 with hepatitis B cirrhosis (LC) and 26 with HBV-related hepatocellular carcinoma Variation of the situation. Results The mutation rates of G1896A and A1762T / G1764A in BCP area of HCC group and LC group were significantly higher than those of CHB group (p≤0.005), but there was no significant difference between HCC group and LC group (p> 0.05). Conclusion The mutations of C gene promoter and pre-C region of hepatitis B virus are closely related to the occurrence of hepatocellular carcinoma and cirrhosis.