早在1653年,Culpeper 在《草药大全》(The Complete Herbal)中就报道,长春花(Catharanthus roseus)可用以止血、止痛和清洗伤口,嗣后,Peckolt 进一步应用长春花治疗坏血病。本世纪初,在南非等地出现了长春花的抗糖尿病制剂。50年代中晚期,Beer 和Johnson 等分别从长春花中提取并发现长春碱(VLB)和长春新碱(VCR)对P1534小鼠白血病的疗效十分显著。此后,长春花生物碱的抗肿瘤作用引起了广泛的注意和深入的研究。 As early as 1653, Culpeper reported in The Complete Herbal that Catharanthus roseus can be used to stop bleeding, relieve pain and wash wounds. Subsequently, Peckolt further applied vinca for the treatment of scurvy. Early this century, anti-diabetic preparations of Catharanthus roseus appeared in South Africa and other places. In the late 1950s, Beer and Johnson, respectively, were extracted from the vinca extract and found that vinblastine (VLB) and vincristine (VCR) P1534 mouse leukemia efficacy is very significant. Since then, the anti-tumor effect of vinca alkaloids aroused a wide range of attention and in-depth study.