1981年有人用静注大剂量免疫球蛋白治疗特发性血小板减少性紫癜(ITP),提示对阻断噬细胞功能有关。ITP通常是一种短暂性疾病,激素治疗有效,少数病人需脾切除,约10%病人变为慢性血小板减少。用灵敏的抗球蛋白方法测定,90%ITP患者血小板相关的免疫球蛋白G(IgG)水平增高,一些脾切除和激素治疗有效的患者则稍有减少。静注免疫球蛋白的效 1981 was intravenous high-dose immunoglobulin treatment of idiopathic thrombocytopenic purpura (ITP), suggesting that blocking the function of the phagocytes. ITP is usually a transient condition, hormone therapy is effective, a small number of patients need splenectomy, about 10% of patients become chronic thrombocytopenia. Sensitive antiglobin assays determined that platelet-associated immunoglobulin G (IgG) levels were elevated in 90% of ITP patients and slightly less in those who were splenectomized and treated with hormone therapy. Intravenous immunoglobulin effect