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胃癌存档石腊组织110例测定其细胞 DNA 含量的 FCM,分析 DNA 倍体及其他病理因素与预后的关系。结果:异倍体的检出率为65%;胃癌患者5年生存率异倍体型与二倍体分别为22.2%和55.3%(P<0.01)。肿瘤浸润深度、生长方式、分化程度、淋巴结转移及 TNM 分期对预后有显著影响,Cox 模型多因素分析结果提示,DNA 倍体是重要影响胃癌预后的独立因素。
The gastric cancer was archived in 110 paraffin tissues to determine the cellular DNA content of FCM. The relationship between DNA ploidy and other pathological factors and prognosis was analyzed. RESULTS: The detection rate of aneuploidy was 65%; the 5-year survival rate of gastric cancer patients was 22.2% and 55.3% for heteroploid and diploid, respectively (P<0.01). The depth of tumor invasion, growth pattern, differentiation, lymph node metastasis, and TNM stage had a significant impact on prognosis. Cox model multivariate analysis suggested that DNA ploidy is an independent factor that significantly affects the prognosis of gastric cancer.