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一些名贵药材中含有相当数量的锗,因此,锗的药用研究受到重视。本实验对我国自行合成的有机锗化合物Ge-132(carboxyethylgermanium sesquioxide,O_3(GeCH_2 CH_2 COOH)_2进行急性毒性、抗肿瘤作用和对NK细胞活性影响的研究。Ge-132毒性很小,其LD_(50)在腹腔注射为2.60±0.18g/kg,口服为12.60±1.14g/kg。Ge-132具有一定的抗肿瘤作用。以0.15～0.30g/kg腹腔给药10次,艾氏腹水癌荷瘤小鼠生命延长30～40％;同样剂量口服或腹腔注射10次。S180肉瘤荷瘤小鼠生命延长30～55％。以YAC-1细胞为靶细胞的~(51)Cr短期释放试验表明,Ge-132能够增强正常和荷瘤小鼠的NK细胞活性。口服Ge-132 0.10、0.20和0.30g/kg后24h,正常Balb/c小鼠脾脏NK细胞活性分别比对照
Some valuable medicinal herbs contain a considerable amount of alfalfa, so the medicinal research of alfalfa is valued. In this experiment, we studied the effects of self-synthesis of organic germanium compound Ge-132 (GeCH 2 CH 2 COOH) 2 on the acute toxicity, anti-tumor activity and NK cell activity. The toxicity of Ge-132 is very small and its LD_ ( 50) Intraperitoneal injection was 2.60±0.18g/kg, orally was 12.60±1.14g/kg, Ge-132 had a certain anti-tumor effect, and was administered intraperitoneally at 0.15-0.30g/kg 10 times, Ehrlich ascites carcinoma The life span of tumor mice was prolonged by 30-40%, and the same dose was orally or intraperitoneally injected 10 times.The life of S180 tumor-bearing mice was prolonged by 30-55%.The short-term release test of ~(51)Cr using YAC-1 cells as target cells Ge-132 can enhance the NK cell activity of normal and tumor-bearing mice.24h after oral administration of Ge-132 0.10, 0.20 and 0.30g/kg, the activity of NK cells in the spleen of normal Balb/c mice was higher than that of the control.