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雌激素是一种类固醇激素,能够抑制兴奋性神经毒性损伤而发挥神经保护作用。雌激素可通过基因组和非基因机制调节谷氨酸NMDA(N-methyl-D-aspartate,N-甲基-D-天冬氨酸)和非NMDA受体,从而调控兴奋性神经毒性和细胞信号传递。研究表明GPR30受体(G-protein-coupled receptor 30,G蛋白耦联受体30)参与局部缺血损伤的神经保护,但是分子机制仍不清楚。本研究首先采用培养的皮层神经元,发现雌二醇和GPR30激
Estrogen is a steroid hormone that exerts neuroprotective effects by inhibiting excitotoxic damage. Estrogen regulates excitatory neurotoxicity and cellular signaling through both genomic and non-genetic mechanisms regulating NMDA (N-methyl-D-aspartate) and non-NMDA receptors transfer. Studies have shown that GPR30 receptor (G-protein coupled receptor 30) is involved in the neuroprotection of ischemic injury, but the molecular mechanism remains unclear. This study first used cultured cortical neurons and found that estradiol and GPR30 agonists