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大量分子生物学的研究表明凋亡失衡在肿瘤的形成中发挥着重要作用。肺癌的发生发展是一多因子、多步骤的复杂生物学过程,与凋亡失衡有着密切的关系。puma是2001年新发现的凋亡相关基因领域新成员之一,是p53的下游靶基因,可通过p53依赖和p53非依赖途径促进细胞凋亡,其介导的凋亡机制在肿瘤包括肺癌发展的多阶段中都起到重要的作用。
A large number of molecular biology studies have shown that imbalance in apoptosis plays an important role in tumor formation. The occurrence and development of lung cancer is a multifactorial and multi-step complex biological process, which is closely related to the imbalance of apoptosis. Puma, a newly discovered member of apoptosis-related genes in 2001, is a downstream target gene of p53, which can promote apoptosis through p53-dependent and p53-independent pathways. Puma-mediated apoptosis mechanisms are involved in the development of tumors including lung cancer The multi-stage play an important role.