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目的:观察阿奇霉素片联合百令胶囊治疗稳定期慢性阻塞性肺疾病(COPD)的疗效和安全性。方法:154例COPD患者随机分为观察组80例和对照组74例。两组患者均给予常规对症治疗,对照组加用百令胶囊1 g,po,tid;观察组在对照组基础上再加用阿奇霉素片250 mg,po,qd。疗程均为6个月,治疗结束后再随访6个月,比较两组临床疗效、肺功能、运动耐量、生活质量、急性加重次数及药品不良反应发生情况。结果:两组患者治疗后肺功能、运动耐量及生活质量均较治疗前明显改善(P<0.05或P<0.01),且观察组患者各项指标明显优于对照组(P<0.05或P<0.01)。观察组总有效率明显高于对照组(P<0.05),急性加重次数明显低于对照组(P<0.01)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿奇霉素片联合百令胶囊可以更好地改善稳定期COPD患者的肺功能,增强运动耐量,提高生活质量,能够有效地减少急性加重的次数,且安全性好。
Objective: To observe the efficacy and safety of azithromycin combined with Bailing capsule in the treatment of chronic obstructive pulmonary disease (COPD) with stable period. Methods: A total of 154 patients with COPD were randomly divided into observation group (80 cases) and control group (74 cases). Two groups of patients were given conventional symptomatic treatment, the control group with Bailing capsule 1 g, po, tid; observation group on the basis of the control group plus azithromycin tablets 250 mg, po, qd. The course of treatment was 6 months. After the treatment, the patients were followed up for 6 months. The clinical efficacy, pulmonary function, exercise tolerance, quality of life, number of acute exacerbations and adverse drug reactions were compared between the two groups. Results: The pulmonary function, exercise tolerance and quality of life of the two groups were significantly improved after treatment (P <0.05 or P <0.01), and the indexes in the observation group were significantly better than those in the control group (P <0.05 or P < 0.01). The total effective rate in the observation group was significantly higher than that in the control group (P <0.05), and the number of acute exacerbations was significantly lower than that in the control group (P <0.01). There was no significant difference between the two groups in the incidence of adverse drug reactions (P> 0.05). Conclusion: Azithromycin tablets combined with Bailing capsule can better improve pulmonary function, improve exercise tolerance and improve quality of life in patients with stable COPD. It can effectively reduce the number of acute exacerbations and has good safety.