论文部分内容阅读
目的:探讨4.1蛋白基因家族(蛋白4.1R,N,G和B)在结直肠癌组织表达的意义.方法:采用Envision~+免疫组织化学的方法,检测94例结直肠癌组织中蛋白4.1R,N,G和B的表达,分析他们与结直肠癌病理特征之间的相关性.结果:结直肠癌组织中,除蛋白4.1G外,蛋白4.1R,N,B在癌组织与癌旁组织之间的表达差异有统计学意义(H_c=44.70,H_c=31.4l,H_c =13.62;均P<0.01);蛋白4.1N和B与患者的细胞分化呈正相关(r_s=0.27,r_s=0.28,均P<0.01);随浸润程度的加深,淋巴结的癌转移,4.1R的表达明显下调(r_s=0.03,P<0.01;r_s=0.24,P<0.05);随浸润程度的加深,4.1G的表达上调(r_s=0.24,P<0.05);4.1蛋白的表达与患者的年龄之间没有相关性,在不同性别之间,4.1蛋白表达的差异没有统计学意义.结论:蛋白4.1家族与结直肠的发生与发展间有着密切的关系,是一类新的结直肠癌标记物,其表达程度对结直肠癌的诊断和预后评价有一定的意义.
Objective: To investigate the significance of 4.1 protein gene family (protein 4.1R, N, G and B) in colorectal cancer tissues.Methods EnVision ~ + immunohistochemistry was used to detect the protein 4.1R , N, G and B in colorectal cancer tissues.Results: In addition to the protein 4.1G, the protein 4.1R, N, B in colorectal cancer tissues was significantly higher than that in the adjacent tissues There was a significant difference between the two groups (H_c = 44.70, H_c = 31.4l, H_c = 13.62; all P <0.01). There was a positive correlation between protein 4.1N and B and cell differentiation (r_s = 0.27, r_s = , All P <0.01). With the deepening of the degree of infiltration, the lymph node metastasis and the expression of 4.1R were significantly down-regulated (r_s = 0.03, P <0.01; r_s = 0.24, (R_s = 0.24, P <0.05). There was no correlation between the expression of 4.1 protein and the patient’s age, and there was no significant difference in the expression of 4.1 protein between different genders.Conclusion: The occurrence and development of rectum is closely related, is a new type of colorectal cancer markers, the degree of expression of colorectal cancer diagnosis and prognosis of a certain significance.