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本文报告了1983/6～1989/5月间,仁济医院102例60岁以上老年进展期胃癌术后病人,应用小金丸加减为主,部分病例加服小剂量喃氟啶(Ftorafurum,FT207)中西医结合组(共50例),与西药化疗组(共52例)的治疗结果,进行前瞻性对照研究,结果表明,小金丸加减方治疗后紫舌证阳性率明显好转,由治疗前58.4%降至治疗后的19.5%,血瘀证改善,血凝指标好转,治疗后 AT-Ⅲ.Fn,Fa 值增高,提示抗凝—纤溶能力增强,ⅧR:Ag 降低,高凝状态改善。1和2年的存活率,中西医结合组明显优于西药组(P<0.05).3和5年的再活率,中西医结合组似优于西药组,但无统计学差异(P>0.05)。毒副反应中西医结合组明显低于西药组。对老年患者化疗往往不能耐受时,小金丸加减使用安全、方便,则更有选用价值。
This article reports that during the period from 1983/6 to 1989/May, 102 patients with advanced gastric cancer who were older than 60 years old in Renji Hospital were treated with Xiaojin Pills, and some patients were given small doses of fludifluoride (Ftorafurum, FT207). The results of the treatment of the combination of TCM and Western medicine group (50 cases in total) and western medicine chemotherapy group (52 cases in total) were prospectively controlled. The results showed that the positive rate of the purple tongue certificate after Xiaojin Pills addition and subtraction prescription improved obviously, from 58.4 before treatment. % decreased to 19.5% after treatment, blood stasis syndrome improved, hemagglutination index improved, AT-III.Fn, Fa values increased after treatment, suggesting that anticoagulant-fibrinolytic ability increased, VIIIR: Ag decreased, and hypercoagulability improved. The 1 and 2 year survival rates were significantly better in the TCM-WM group than in the western medicine group (P<0.05). The reactivation rate was 3 and 5 years. The TCM-WM group appeared to be better than the Western medicine group, but there was no statistical difference (P> 0.05). The toxic side effects of the TCM-WM group were significantly lower than the western medicine group. When elderly patients are often unable to tolerate chemotherapy, the addition and subtraction of Xiaojin Pill is safe and convenient.