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Ⅲ型前胶原的氨基末端前肽(PⅢNP)是Ⅲ型前胶原向Ⅲ型胶原转化时前者的氨基末端被切下的肽段,并释放到血清中。血清中PⅢNP的升高意味着胶原合成、沉积、变性和清除代谢的增强。已证实血清中PⅢNP水平与急性心肌梗死病人梗塞面积的大小有关,并有助于判断病人的预后。本实验旨在评价血清中PⅢNP水平的升高是否与心梗后左室功能变化
The amino-terminal propeptide (PⅢNP) of type Ⅲ procollagen is a peptide in which the amino terminus of the former is cleaved when procollagen III is transformed into type III collagen and released into the serum. Increased PIIINP in serum means increased collagen synthesis, deposition, degeneration, and clearance of metabolism. PⅢNP levels in serum have been shown to correlate with infarct size in patients with acute myocardial infarction and to help determine patient outcomes. The aim of this experiment was to evaluate whether elevated serum PⅢNP level correlates with left ventricular function after myocardial infarction