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目的 :探讨引起药物性肝损伤(DILI)的药物种类及其临床特点。方法 :回顾性总结我院近10年DILI住院患者的临床资料,分析其使用药物、临床表现、肝损害及治疗转归。结果 :35例DILI中男12例,女23例,男女比例为1∶1.9。平均年龄53.5±15.0岁,其中55岁及以上者占57.1%。引起肝损伤的药物中,中药17例,西药18例,降脂药、抗生素和抗肿瘤药为引起DILI前三位的西药。男性患者的GGT水平明显高于女性患者,55岁以下患者的ALT水平明显高于55岁及以上年龄组。结论 :中药引起的DILI不容忽视,DILI好发于中老年女性,在使用具有潜在肝损伤的药物时需格外谨慎。
Objective: To explore the types of drugs and clinical features of drug induced liver injury (DILI). Methods: To retrospectively summarize the clinical data of hospitalized patients with DILI in our hospital for nearly 10 years and analyze the use of drugs, clinical manifestations, liver damage and treatment outcome. Results: There were 12 males and 23 females in 35 cases of DILI, the male-female ratio was 1: 1.9. The average age was 53.5 ± 15.0 years, of which 57.1% were 55 and over. Among the drugs that cause liver injury, 17 cases are traditional Chinese medicine and 18 cases western medicine. The lipid-lowering drugs, antibiotics and anticancer drugs are the top three western medicines that cause DILI. The GGT level in male patients was significantly higher than that in female patients, and the ALT levels in patients under 55 years old were significantly higher than those in the 55 years old and above. Conclusion: The DILI caused by traditional Chinese medicine should not be neglected. DILI is more common in middle-aged and elderly women and should be used with caution when using drugs with potential liver damage.