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急性呼吸道感染(ARI)是儿童最常见的感染,2岁以下儿童发病率尤高。感染的危险因素包括男性、被动吸烟以及生活条件拥挤。甘露糖结合植物血凝素(MBL)是血清中的一种蛋白质,在体内免疫反应中起重要作用。人类MBL由定位于10号染色体上单基因MBL2编码。MBL与微生物表面富含甘露糖和N-乙酰氨基葡萄糖的寡糖结合,通过MBL相关丝氨酸蛋白酶激活补体系统以及与吞噬细胞表面受体结合而发挥作用。这种蛋白质在易感
Acute respiratory infections (ARI) are the most common infections in children, with a particularly high incidence in children under 2 years of age. Risk factors for infection include males, passive smoking and overcrowded living conditions. Mannose-binding phytohemagglutinin (MBL) is a protein in serum that plays an important role in the immune response in vivo. Human MBL is encoded by a single gene MBL2 located on chromosome 10. MBL binds to oligosaccharides rich in mannose and N-acetylglucosamine on the surface of microorganisms and plays a role by activating the complement system by MBL-associated serine protease and binding to the surface receptors of phagocytes. This protein is susceptible