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自分泌运动因子(autocrine motility factor,AMF)能刺激细胞的迁移和运动,与肿瘤发生、转移、血管生成密切相关。近年来人们发现有3种AMF:ATX-t、ATX-m和PD-Ialpha,其中PD-Ialpha在脑中特异表达,在神经发育、生长和神经分化、神经外伤修复与神经性疼痛以及神经退行性疾病中具有重要的作用,提示AMF及其受体与神经系统的病理生理过程密切相关。该文就AMF及其受体在神经系统中的作用和作用机制作一综述,为相关的研究提供参考。
Autocrine motility factor (AMF) can stimulate cell migration and motility, which is closely related to tumorigenesis, metastasis and angiogenesis. In recent years, three kinds of AMFs have been found: ATX-t, ATX-m and PD-Ialpha. PD-Ialpha is specifically expressed in the brain and plays an important role in neurodevelopment, growth and neural differentiation, neurotrauma repair and neuropathic pain, Sexual disease plays an important role, suggesting that AMF and its receptors and the nervous system pathophysiology is closely related. This review summarizes the roles and mechanisms of AMF and its receptors in the nervous system and provides references for related research.