黄芩苷β-环糊精包合物脂质体的制备与药动学研究

来源 :西北药学杂志 | 被引量 : 0次 | 上传用户：xoyo20001

【摘要】

：

目的制备黄芩苷β-环糊精(β-CD)包合物脂质体,并考察其在大鼠体内的药动学。方法采用饱和水溶液法制备黄芩苷β-CD包合物,以包合率作为评价指标,通过正交实验考察搅拌速度、水浴温度以及药物与载体质量比3个因素对黄芩苷β-CD包合物包合率的影响,并得到最佳制备工艺参数和处方;采用傅里叶红外变换光谱法(FTIR)确认了黄芩苷β-CD包合物的形成;采用薄膜-超声分散法制备黄芩苷β-CD包合物脂质体,并测定脂质体的粒径分布、Zeta电位以及在不同pH值介质环境中体外药物释放情况;通过Wister大鼠口服给予黄芩苷

【作者】

：

余清

【机构】

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湖北六七二中西医结合骨科医院药学部

【出处】

：

西北药学杂志

【发表日期】

：

2021年4期

【关键词】

：

黄芩苷 β-环糊精(β-CD) 包合物脂质体药动学生物利用度

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黄芩苷β-环糊精包合物脂质体的制备与药动学研究

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