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结直肠癌肝转移的化疗效应与剂量有关。动物实验表明,肝动脉注射化疗药物加可降解的淀粉微球(D-SMs)可使肿瘤与肝间的血流重新分配,并使肿瘤内药物浓度增加,但在人类无类似报道。作者对大肠癌肝转移的病人进行前瞻性临床研究,旨在评估术中肝动脉联合给药后DSMs 对肿瘤和肝组织的氟去氧尿嘧啶核甙(FUdR)浓度的影响。结直肠癌肝转移14例,其中7例双侧性病变无法切除,行肝动脉内化疗,另7例病灶局限,适合肝切除术。不能切除的7例中8例为对照活检组,4例为DS-Ms 活检组。能切除的7例为DSMs 切除组。每例需肝
The chemotherapy effect of colorectal liver metastases is related to the dose. Animal experiments showed that hepatic arterial injection of chemotherapeutic drugs plus degradable starch microspheres (D-SMs) can redistribute the blood flow between the tumor and liver, and increase the concentration of drugs in the tumor, but no similar reports in humans. The authors conducted a prospective clinical study of patients with liver metastases of colorectal cancer to evaluate the effect of DSMs on the concentration of fluorodeoxyuridine (FUdR) in tumors and liver tissues after intrahepatic arterial administration. There were 14 cases of colorectal liver metastases, of which 7 cases of bilateral lesions could not be resected, and intrahepatic arterial chemotherapy was performed. The other 7 cases were limited in lesions and were suitable for hepatectomy. Of the 7 cases that could not be removed, 8 were control biopsies and 4 were DS-Ms biopsies. Seven of the excised cases were DSMs. Each case requires liver