单克隆抗体已初步被应用于现代抗肿瘤治疗中,它可分为非结合型与结合型两种。后者主要包括与放射性同位素结合、与化疗药物结合、与生物毒素结合的单克隆抗体。上述单克隆抗体在实验室中已证实具有抗肿瘤作用,在临床使用有一定疗效。目前尚有靶区抗体浓度低、鼠抗体对人体的免疫原性等问题有待解决。 Monoclonal antibodies have been initially used in modern anti-tumor therapy, which can be divided into non-binding and binding types. The latter mainly includes monoclonal antibodies that bind to radioisotopes, bind to chemotherapeutic drugs, and bind to biotoxins. The above-mentioned monoclonal antibodies have been proved to have an anti-tumor effect in the laboratory and have a certain curative effect in clinical use. At present, there are still problems such as low antibody concentration in target areas and immunogenicity of mouse antibodies against human body.