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目的 研究大肠癌患者血清糖链抗原CA5 0表达水平及其临床意义。方法 采用免疫放射分析法 (IR MA)对 73名正常人 ,3 3例大肠良性疾病及 13 6例大肠癌患者进行了血清CA5 0水平测定 ,同时用ELISA法测定了大肠癌患者血清CEA水平。结果 大肠癌患者血清CA5 0水平 (41.6± 3 0 .9u/ml)显著高于正常人 (8.9± 5 .5u/ml,P <0 .0 1)及良性疾病组 (11.2± 7.6u/ml ,P <0 .0 1)。以 2 0u/ml为阳性界值 ,CA5 0对诊断大肠癌的灵敏度为 72 .1% ,特异性为91.5 % ,有效率 82 .8%。血清CA5 0水平升高与大肠癌临床分期、复发和转移等因素密切相关。大肠癌患者血清CA5 0与CEA水平呈正相关 (r =0 .5 8,P <0 .0 1)。结论 CA5 0可作为大肠癌诊断和临床分期的辅助指标之一 ,有助于鉴别大肠疾病的良恶性 ,对病情变化、预后及疗效的判定有一定参考价值
Objective To study the expression of serum carbohydrate antigen CA5 0 in patients with colorectal cancer and its clinical significance. Methods Immunoradiometric assay (IRMA) was used to measure serum CA50 levels in 73 healthy individuals, 33 patients with benign colorectal disease and 136 patients with colorectal cancer. Serum CEA levels in patients with colorectal cancer were measured by ELISA. Results The serum CA5 0 level in patients with colorectal cancer (41.6 ± 30. 9u/ml) was significantly higher than that in normal controls (8.9 ± 5 .5u/ml, P <0.01) and the benign disease group (11.2 ± 7.6u/ml). , P <0. 0 1). With 20 u/ml as the positive cutoff value, the sensitivity of CA50 in the diagnosis of colorectal cancer was 72.1%, the specificity was 91.5%, and the effective rate was 82.8%. The increase of serum CA50 levels is closely related to the clinical stage, recurrence, and metastasis of colorectal cancer. There was a positive correlation between serum CA50 and CEA levels in patients with colorectal cancer (r = 0.58, P < 0.01). Conclusion CA50 can be used as one of the auxiliary indicators for the diagnosis and clinical staging of colorectal cancer, and it is helpful to distinguish the benign from malignant diseases of the large intestine. It has certain reference value for the determination of the disease, prognosis and curative effect.