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吞噬细胞虽已研究了几十年,但近年来对巨噬细胞研究又进入热潮,这是因为巨噬细胞不仅参与肿瘤免疫、非特异性与特异性免疫及杀菌作用;而且还有分泌功能,甚至有人认为分泌功能比吞噬功能更重要。本文仅就“巨噬细胞与抗感染”作一概要介绍。一、巨噬细胞的分化、发育与名称过去将巨噬细胞归入网状内皮系统,而今列入单核——吞噬细胞系统(mononuclear——phagocytic system),这是由于巨噬细胞均来源于单核细胞。骨髓多能干细胞中的单核母细胞(monoblasts)分裂为前单核细胞(promonocytes)再进一步分化为直径12—18微米的单核细胞(monocytes),随后进入血流,当机体生理功能正常时,能
Although phagocytes have been studied for decades, the study of macrophages has entered a boom in recent years because macrophages are not only involved in tumor immunity, non-specific and specific immunity and bactericidal effects, but also have secretory functions and even Some people think that secretion is more important than phagocytosis. This article only on “macrophages and anti-infectives” for a brief introduction. I. THE DIFFERENTIATION, DEVELOPMENT AND NAMES OF MACROPHAGES Historically, macrophages were classified as reticuloendothelial systems and are now included in the mononuclear-phagocytic system, as macrophages are derived from Monocytes. Monoblasts in myeloid pluripotent stem cells divide into pre-mononuclear cells and then further differentiate into monocytes 12-18 μm in diameter, and then into the bloodstream. When the physiological function of the body is normal ,can