论文部分内容阅读
本室曾提出,胆碱能神经系统的激动可能在感染性休克的发病学上有一定意义。但氨今时感染性休克过程中胆碱能神经递质乙酰胆碱(ACh)代谢各环节的变化了解甚少。本文以水解ACh并中止其递质作用的乙酰胆碱酯酶(AChE)为指标,观察了内毒素休克动物红细胞AChE活性的变化以及内毒素对正常红细胞AChE在体外的直接作用。 材料与方法 (一)活体实验 兔.1.8～2.5kg,对照组5只,注生理盐水;内毒素(ET)休克组6只,静注LD_(100)的大肠杆菌ET(自制)10～20mg/kg;出血性休克组6只,动脉放血使血压维持至40mmHg水平。猫:
This room had been proposed, cholinergic nervous system activation may have some significance in the pathogenesis of septic shock. However, ammonia in the process of septic shock during the cholinergic neurotransmitter acetylcholine (ACh) changes in the metabolism of little understanding. In this paper, acetylcholinesterase (AChE), which hydrolyzes ACh and stops its neurotransmitter, was used as an index to observe the change of AChE activity of erythrocytes in endotoxic shock animals and the direct effect of endotoxin on normal erythrocyte AChE in vitro. MATERIALS AND METHODS (1) In vivo experiments Rabbits 1.8 ~ 2.5kg, control group 5, saline; endotoxin (ET) shock group 6, intravenous LD_ (100) of E.coli ET (homemade) 10 ~ 20mg / kg; hemorrhagic shock group 6, arterial blood pressure to maintain blood pressure to 40mmHg level. Cat: