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各种食物添加剂、食物污染和微量的其他外源性化合物进入人体后不仅在肝脏,而且在肝外组织进行代谢。在小肠细胞内,外源性物质被氧化,而后结合成水溶性衍生物经肾或胆道排出,或经肠细胞再排至肠腔。肠粘膜的芳香基碳水化物水解酶(AHH)活性以近端小肠最高,向下逐渐降低。多环碳水化物首先经AHH作用生成具有高度毒性的代谢产物——环氧化物,它具有致突变和致癌作用。环氧化物经环氧化物水解酶(EH)催
A variety of food additives, food contamination and trace amounts of other exogenous compounds enter the body not only in the liver, but also in extrahepatic tissue metabolism. In small intestine cells, exogenous substances are oxidized, and then combined into a water-soluble derivatives by the kidneys or biliary excretion, or intestinal cells and then discharged to the intestine. Intestinal mucosa of aromatic carbohydrate hydrolase (AHH) activity in the proximal intestine highest, gradually decreased downward. Polycyclic carbohydrates are first metabolized by AHH to produce highly toxic metabolites - epoxides, which have mutagenic and carcinogenic effects. Epoxides are catalysed by the epoxide hydrolase (EH)