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目的探讨CD44V6基因蛋白在甲状腺乳头状腺癌组织的表达及其临床意义。方法用免疫组织化学S-P法,检测印例甲状腺乳头状腺癌,12例甲状腺滤泡性腺瘤组织中CD44V6基因蛋白的表达情况,并分析其临床病理意义。结果CD44V6在甲状腺乳头状腺癌与甲状腺滤泡性腺瘤表达差异有极显著意义(P＜0．01);甲状腺乳头状腺癌颈淋巴结转移组表达阳性率与无颈淋巴结转移组差异有极显著意义(P＜0．01)。p53蛋白在甲状腺乳头状腺癌染色阳性率为68．3%(41/60);p53蛋白在甲状腺滤泡性腺瘤染色均阴性。甲状腺乳头状腺癌颈淋巴结转移组表达阳性率与无颈淋巴结转移组阳性率差异无显著意义(P＞0．05)。结论CD44V6异常表达与甲状腺乳头状腺癌的恶性行为有关,CD44V6的检测对于甲状腺乳头状腺癌的诊断及转移潜能的判断具有一定临床意义。
Objective To investigate the expression of CD44V6 protein in papillary thyroid carcinoma and its clinical significance. Methods The immunohistochemical S-P method was used to detect the expression of CD44V6 protein in thyroid papillary adenocarcinoma and 12 cases of thyroid follicular adenoma. The clinicopathological significance was analyzed. Results There was a significant difference in the expression of CD44V6 between thyroid papillary adenocarcinoma and thyroid follicular adenoma (P <0.01). The positive rate of CD44V6 in cervical lymph node metastasis was significantly different from that in cervical lymph node metastasis Significance (P <0.01). The positive rate of p53 protein staining in thyroid papillary adenocarcinoma was 68.3% (41/60). The expression of p53 protein was negative in thyroid follicular adenoma. The positive rate of cervical lymph node metastasis in patients with papillary thyroid carcinoma had no significant difference (P> 0.05). Conclusion The abnormal expression of CD44V6 is associated with the malignant behavior of thyroid papillary adenocarcinoma. The detection of CD44V6 is of clinical significance for the diagnosis and metastatic potential of thyroid papillary adenocarcinoma.