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目的探讨人工肝联合中药灌肠治疗乙肝肝衰竭的临床效果及安全性。方法选取48例乙肝肝衰竭患者,随机分为治疗组25例与对照组23例,对照组给予内科综合治疗+人工肝治疗+乳果糖灌肠,治疗组给予内科综合治疗+人工肝治疗+中药灌肠。观察治疗后2组症状、体征及实验室指标的变化,并判定临床疗效,观察2组不良反应发生情况。结果治疗后治疗组临床总有效率显著高于对照组(P<0.05),总胆红素、谷丙转氨酶、凝血酶原活动度、白蛋白水平均较对照组明显改善(P均<0.05),血氨水平与对照组相比无统计学意义(P>0.05),不良反应发生率显著低于对照组(P<0.05)。结论人工肝联合中药灌肠治疗乙肝肝衰竭安全且有效。
Objective To investigate the clinical effect and safety of artificial liver combined with traditional Chinese medicine enema on hepatitis B liver failure. Methods Forty-eight patients with hepatitis B liver failure were selected and randomly divided into treatment group (n = 25) and control group (n = 23). The control group was given comprehensive medical therapy and artificial liver treatment plus lactulose enema. The treatment group was given comprehensive medical treatment, artificial liver treatment and traditional Chinese medicine enema . After treatment, the changes of symptoms, signs and laboratory indexes of 2 groups were observed, and the clinical curative effect was observed. The occurrence of adverse reactions in 2 groups were observed. Results After treatment, the total effective rate of the treatment group was significantly higher than that of the control group (P <0.05). The total bilirubin, alanine aminotransferase, prothrombin activity and albumin level were significantly improved (P <0.05) (P> 0.05). The incidence of adverse reactions was significantly lower than that of the control group (P <0.05). Conclusion Artificial liver combined with traditional Chinese medicine enema treatment of hepatitis B liver failure is safe and effective.