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为了解白血病治疗过程中的抗凝、凝血及纤溶的变化,采用一期法及单向免疫扩散法对52例白血病患者进行血浆蛋白C活性、因子Ⅷ活性及纤溶酶原的动态检测,同时以30例健康人作正常对照。结果表明:急性白血病患者血浆蛋白C活性治疗前明显低于对照组(t=3.218,P<0.01),完全缓解期接近对照组(t=0.899,P>0.05);因子Ⅷ活性治疗前明显低于对照组(t=4.152,P<0.01),完全缓解期仍低于对照组(t=3.365,P<0.01)。慢性粒细胞白血病患者血浆蛋白C及因子Ⅷ活性治疗前明显低于对照组(t=5.598、2.649,P<0.01)。各期纤溶酶原均无明显变化。
In order to understand the changes of anticoagulation, coagulation and fibrinolysis during the treatment of leukemia, a single-phase method and one-way immunodiffusion method were used to detect plasma protein C activity, factor VIII activity and plasminogen dynamics in 52 patients with leukemia. At the same time, 30 healthy people were used as normal controls. The results showed that plasma protein C activity in patients with acute leukemia was significantly lower before treatment than in the control group (t=3.218, P<0.01), and complete remission was close to the control group (t=0.899, P>0.05); factor VIII activity was significantly lower before treatment In the control group (t=4.152, P<0.01), the complete remission period was still lower than the control group (t=3.365, P<0.01). Plasma protein C and factor VIII activity in patients with chronic myelogenous leukemia before treatment was significantly lower than the control group (t = 5.598, 2.649, P <0.01). There was no significant change in plasminogen levels at each stage.