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在实验室模拟移动床(SMB)分离设备上成功地实现了木糖醇母液中木糖和木糖醇组份的分离提纯。并在平衡理论的框架下,采用基于真实移动床(TMB)的简化数学模型,以产品纯度和收率为系统分离性能的优化指标,研究SMB分离性能与操作条件之间的关系。通过对木糖醇母液SMB色谱分离过程操作条件的寻优仿真研究,确定稳态时柱内的木糖和木糖醇浓度分布状态;计算出不同操作条件时两组分产品液各自的纯度和收率变化规律图。在阀门切换时间为15min,进料木糖醇母液中木糖浓度35gL-1,木糖醇浓度114gL-1,进料和出料总量恒定为16mLmin-1,循环洗脱剂流量恒定为18mLmin-1的操作条件下,木糖醇母液进料流量在1~2.3mLmin-1范围内都可同时获得纯净木糖醇与木糖产品。在实验室SMB分离设备上进行了验证,得到的木糖和木糖醇产品液纯度和收率均达到了100%,所有实验结果与仿真曲线基本吻合。因此采用基于TMB的简化的平衡理论模型进行仿真和优化研究可分析和预测木糖母液SMB色谱分离系统操作条件对系统分离性能的影响,有效地指导了产品分离实验、工业化放大设计和生产优化操作。
The separation and purification of the xylose and xylitol components from the xylitol mother liquor was successfully performed on a laboratory simulated moving bed (SMB) separation equipment. In the framework of the equilibrium theory, a simplified mathematical model based on a real moving bed (TMB) was used to study the relationship between the performance of SMB separation and operating conditions based on product purity and yield as an optimization index of system separation performance. Through the optimization of the operating conditions of the xylitol mother liquor SMB chromatographic separation process to determine the steady-state column of xylose and xylitol concentration distribution; calculated under different operating conditions, the purity of two product liquid and Yield variation chart. In the valve switching time of 15min, the xylitol mother liquor feed xylose concentration of 35gL-1, xylitol concentration of 114gL-1, the total amount of feed and the discharge constant 16mLmin-1, the flow of circulating eluent constant 18mLmin -1 under the operating conditions, the xylitol mother liquor feed flow in the range of 1 ~ 2.3mLmin-1 can be obtained at the same time pure xylitol and xylose products. In the laboratory SMB separation equipment was verified, the resulting xylose and xylitol product liquid purity and yield were 100%, all the experimental results and the simulation curve is basically consistent. Therefore, the simulation and optimization based on the simplified balanced theoretical model based on TMB can analyze and predict the influence of operating conditions on the separation performance of the system, and effectively guide the product separation experiment, industrialized design and production optimization .