正定霉素(Daunoblastina,Farmitalia)是从链球菌中分离出的一种新型抗肿瘤药物,在体内体外对休止期细胞和增殖期细胞均有抑制作用,明显降低有丝分裂指数,抑制大鼠和小鼠实体瘤和腹水瘤生长,显著延长带瘤动物生存时间。本药毒性较低、治疗指数较高。其作用机制为阻断核酸的合成。 适应症 急性白血病(淋巴母细胞型,成髓细胞型、原单核细胞型、血细胞型及干细胞型),慢性髓性白血病(网状细胞肉瘤、淋巴肉瘤)、成神经细胞瘤、横纹肌细胞瘤。 Daunoblastina (Farmitalia), a novel antitumor drug isolated from Streptococcus, has inhibitory effects on both resting and proliferating cells both in vivo and in vitro, significantly reduces the mitotic index and inhibits both rat and mouse Solid tumors and ascites tumor growth, significantly prolong the survival time of tumor-bearing animals. The drug is less toxic, higher therapeutic index. Its mechanism of action is to block the synthesis of nucleic acids. Indications Acute leukemia (lymphoblastoid, myeloblastic, primitive monocytic, hematopoietic and stem cell types), chronic myeloid leukemia (reticulocytic sarcoma, lymphosarcoma), neuroblastoma, rhabdomyosarcoma.