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早期发现、阻断和逆转肝纤维化是治疗慢性肝病的关键。目前肝纤维化的发病机制仍不十分明确,细胞因子在肝纤维化形成中的作用已受到重视,为此,我们对88例慢性乙型病毒性肝炎和肝炎肝硬变患者同时检测了血清IL-6活性、血清Ⅲ型前胶原蛋白(PCⅢ)、层粘连蛋白(LN)、透明质酸酶(HA)含量,并与其中27例肝组织学结果进行对照研究,以探讨IL-6在慢性肝病肝纤维化形成中的意义。 1 材料和方法 1.1 材料 我科住院患者88例,男62例,女26例,年龄17岁～68岁,诊断符合1995年北京第五次全国传染病与寄生虫病
Early detection, block and reverse liver fibrosis is the key to the treatment of chronic liver disease. At present, the pathogenesis of liver fibrosis is still not very clear, the role of cytokines in the formation of liver fibrosis has been taken seriously, therefore, we 88 patients with chronic hepatitis B and hepatitis cirrhosis were detected serum IL -6 activity, PCⅢ, LN, and HA in 27 patients with hepatocellular carcinoma (HCC) were compared with those of 27 patients with HCC to explore the role of IL-6 in chronic Significance of liver fibrosis formation. 1 Materials and Methods 1.1 Materials Our hospitalized patients 88 cases, 62 males and 26 females, aged 17 to 68 years old, the diagnosis in line with the 1995 Beijing Fifth National Infectious and Parasitic Diseases