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目的探讨厄贝沙坦与苯那普利分别联合硝苯地平对高血压病(HL)左室肥厚(LVH)的疗效观察。方法选择134例HL合并LVH患者,随机分为治疗组(67例)和对照组(67例)两组,治疗组口服厄贝沙坦150～300mg,1次/d,和硝苯地平缓释片20 mg,2次/d。对照组口服苯那普利10 mg,1～2次/d,和硝苯地平缓释片20 mg,2次/d,疗程6个月,观察治疗前后血压及LVH指标。结果两组患者治疗后均能显著降低血压和逆转LVH的各项指标(P<0.01),且治疗组较对照组更为显著(P<0.01)。结论厄贝沙坦联合硝苯地平与苯那普利联合硝苯地平均能有效的控制血压和逆转高血压LVH,其中厄贝沙坦联合硝苯地平疗效更为显著。
Objective To investigate the curative effect of irbesartan and benazepril combined with nifedipine on left ventricular hypertrophy (LVH) in patients with essential hypertension (HL). Methods A total of 134 patients with HL and LVH were enrolled and randomly divided into treatment group (67 cases) and control group (67 cases). The treatment group was treated with irbesartan 150 ~ 300mg, once daily and nifedipine 20 mg tablets, 2 times / d. The control group was treated with benazepril 10 mg, once or twice a day, and nifedipine sustained-release tablets 20 mg twice daily for 6 months. The blood pressure and LVH index were observed before and after treatment. Results After treatment, both groups could significantly lower blood pressure and reverse LVH (P <0.01), and the treatment group was more significant than the control group (P <0.01). Conclusion Irbesartan combined with nifedipine and benazepril combined with nifedipine can effectively control blood pressure and reverse the hypertensive LVH, irbesartan and nifedipine more effective.