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Evodiamine-inspired Dual Histone Deacetylase 1(HDAC1)and Topoisomerase 2(Top 2)Inhibitors with Poten
[会议论文] 作者：Guoqiang Dong,
来源：2019中国化学会第十五届全国计算(机)化学学术会议 年份：2019
A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds with therapeutic advantages over single target inhibitors and drug combinations.Inspired by our previous eff...
Effects of Different Diets on the Dietary Attractability and Selectivity of Chinese Shrimp, Fennerop
[期刊论文] 作者：Huang Guoqiang,Dong Shuanglin,,
来源：黑龙江科技学院学报 年份：2005
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7...
[会议论文] 作者：Guoqiang Dong,Wannian Zhang,Chunquan Sheng,
来源：第七届全国化学生物学学术会议 年份：2011
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[期刊论文] 作者：Ying Wu,Guoqiang Dong,Chunquan Sheng,
来源：药学学报（英文版） 年份：2020
Necroptosis,a genetically programmed form of necrotic cell death,serves as an important pathway in human diseases.As a critical cell-killing mechanism,necroptos...
Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with
[期刊论文] 作者：Yahui Huang,Shuqiang Chen,Shanchao Wu,Guoqiang Dong,Chunquan Sheng,
来源：药学学报（英文版） 年份：2020
A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds with therapeutic advantages over single target inhibitors and drug c...
,Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mecha
[期刊论文] 作者：Shuqiang Chen,Guoqiang Dong,Shanchao Wu,Na Liu,Wannian Zhang,Chunquan Sheng,
来源：药学学报（英文版） 年份：2019
Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents.However,the clinical development of these compounds...
[会议论文] 作者：XING Wenhua,PAN Haijing,FANG Guoqiang,DONG Hui,YIN Yingjie,ZHANG Yin,
来源：第八届北京五洲国际心血管病会议 年份：2014
Objective To assess whether renal insufficiency is significant independent predictors of coronary artery disease.Methods We enrolled 1394 coronary artery disease patients undergoing coronary angiograp...
Structural and mechanical properties of TiON nanocomposite films deposited on silicon by pulsed bias
[会议论文] 作者：Zhang Min,Zhao Shuang,PAN Yanwei,Chen Jiayin,Lin Guoqiang,Dong Chuang,
来源：2014国际高能束与特种能场制造暨第五届高能束流加工技术国际学术会议 年份：2014
Nanocomposite TiON thin films were deposited on p-(100) silicon substrate using a pulsed bias arc ion plating technique with the substrate bias ranging from 0V to-700V.XRD and TEM were used to charact...
[期刊论文] 作者：HUANG Yong,LI Guangming,DING Jun,DAI Jie,YAN Guoqiang,DONG Suiliang,HUANG Hanxiao,,
来源：Acta Geologica Sinica(English Edition) 年份：2017
The newly discovered Zhunuo porphyry Cu-Mo-Au deposit is located in the western part of the Gangdese porphyry copper belt in southern Tibet, SW China. The grani...
[期刊论文] 作者：Shipeng He,Junhui Ma,Yuxin Fang,Ying Liu,Shanchao Wu,Guoqiang Dong,Wei Wang,Chunquan Sheng,
来源：药学学报（英文版） 年份：2021
The dose-related adverse effects of MDM2-P53 inhibitors have caused significant concern in the development of clinical safe anticancer agents.Herein we report an unprecedented homo-PROTAC strategy for more effective disruption of MDM2-P53 i......
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