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Substrate recognition and motive mode analyses of PFV integrase complexed with viral DNA via coarse-
[会议论文] 作者:Jian-ping Hu,Hong-qiu He,Shan Chang,
来源:第五届全国生物信息学与系统生物学学术大会 年份:2012
HIV-1 integrase (IN) is an important target in the development of drugs against the AIDS virus.The drug design based on the structure of IN was markedly hampered due to the lack of three-dimensional s...
Understanding the folding and stability of a designed WW domain protein with replica exchange molecu
[会议论文] 作者:Jian-ping Hu,Hong-qiu He,Xiong Jiao,Shan Chang,
来源:第七届国际分子模拟与信息技术应用学术会议 年份:2014
WW domain proteins are usually regarded as simple models for understanding the folding mechanisrn of β-sheet.CC45 is an artificial protein that is capable of folding into the same structure as WW doma...
[会议论文] 作者:Jian-Ping Hu,Xiao-jun Gou,Hua wan,Shah Chang,Hong-qiu He,
来源:第十二届全国计算(机)化学学术会议 年份:2013
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,A novel high-throughput format assay for HIV-1 integrase strand transfer reaction using magnetic be
[期刊论文] 作者:Hong-qiu HE,Xiao-hui MA,Bin LIU,Wei-zu CHEN,Cun-xin WANG,Shao-hui CHENG,
来源:中国药理学报(英文版) 年份:2008
Aim:To develop a novel high-throughput format assay to monitor the integrase (IN) strand transfer (ST) reaction in vitro and apply it to a reaction character st...
High-throughput real-time assay based on molecular beacons for HIV-1 integrase 3’-processing reactio
[期刊论文] 作者:Hong-qiu HE,Xiao-hui MA,Bin LIU,Xiao-yi ZHANG,Wei-zu CHEN,Cun-xin WANG,Shao-hui CHENG,
来源:中国药理学报(英文版) 年份:2007
Aim: To develop a high-throughput real-time assay based on molecular beacons to monitor the integrase 3’-processing reaction in vitro and apply it to inhibitor...
[期刊论文] 作者:Zai-Gang Luo,Yu Zhao,Chao Ma,Xue-Mei Xu,Xiao-Mei Zhang,Nian-Yu Huang,Hong-Qiu He,,
来源:Chinese Chemical Letters 年份:2014
A series of novel calix[4]arene derivatives incorporating two triazolyl 1 3-diketo subunits in alternate positions at the lower rim were synthesized and screene...
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